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Publication
Diet-induced increases in adiposity, but not plasma lipids, promote macrophage
infiltration into white adipose tissue.
Authors Coenen KR, Gruen ML, Chait A, Hasty AH
Submitted By Alyssa Hasty on 11/6/2007
Status Published
Journal Diabetes
Year 2007
Date Published
Volume : Pages 56 : 564 - 573
PubMed Reference 17327423
Abstract Obesity, hyperlipidemia, and insulin resistance are cardinal features of the
metabolic syndrome and individually increase the risk for developing diabetes
and cardiovascular disease, a risk that is amplified when they are
simultaneously present. It is becoming increasingly clear that macrophages can
infiltrate white adipose tissue (WAT) in the obese state, and their presence is
associated with pathophysiological consequences of obesity, such as inflammation
and insulin resistance. To determine whether hyperlipidemia could potentiate
macrophage infiltration into WAT in the presence of obesity, obesity-prone
agouti yellow mice (A(y)/a) on a hyperlipidemia-prone LDL receptor
(LDLR)-deficient (LDLR(-/-)) background were placed on chow or Western diet. In
addition, A(y)/a mice that were LDLR sufficient were also placed on Western
diet. Both genetics and diet increased the degree of adiposity; however, plasma
lipids were elevated only in the Western diet-fed LDLR(-/-) mice. The extent of
macrophage accumulation in WAT correlated with the degree of adiposity. However,
hyperlipidemia did not impact macrophage recruitment to WAT or the downstream
metabolic consequences of macrophage accumulation in WAT, such as inflammation
and insulin resistance. These data have important implications for the
pathogenesis of diet-induced obesity in humans, even when plasma lipid
abnormalities are not present.




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