mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Publication
Echocardiographic evaluation of ventricular function in mice.
Authors Rottman JN, Ni G, Brown M
Submitted By Jeff Rottman on 11/12/2007
Status Published
Journal Echocardiography (Mount Kisco, N.Y.)
Year 2007
Date Published 1/1/2007
Volume : Pages 24 : 83 - 89
PubMed Reference 17214630
Abstract Ventricular dysfunction remains a hallmark of most cardiac disease. The mouse
has become an essential model system for cardiovascular biology, and
echocardiography an established tool in the study of normal and genetically
altered mice. This review describes the measurement of ventricular function,
most often left ventricular function, by echocardiographic methods in mice.
Technical limitations related to the small size and rapid heart rate in the
mouse initially argued for the performance of echocardiography under anesthesia.
More recently, higher frame rates and smaller probes operating at higher
frequencies have facilitated imaging of conscious mice in some, but not all,
experimental protocols and conditions. Ventricular function may be qualitatively
and quantitatively evaluated under both conditions. Particular detail is
provided for measurement under conscious conditions, and measurement under
conscious and sedated or anesthestized conditions are contrasted. Normal values
for echocardiographic indices for the common C57BL/6 strain are provided.
Diastolic dysfunction is a critical pathophysiologic component of many disease
states, and progress in the echocardiographic evaluation of diastolic function
is discussed. Finally, echocardiography exists among several competing imaging
technologies, and these alternatives are compared.




Catalog Groups / Subjects

Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.