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Publication
NIH Mouse Metabolic Phenotyping Centers: the power of centralized phenotyping.
Authors Laughlin MR, Lloyd KC, Cline GW, Wasserman DH
Submitted By David Wasserman on 9/27/2012
Status Published
Journal Mammalian genome : official journal of the International Mammalian Genome Society
Year 2012
Date Published
Volume : Pages 23 : 623 - 631
PubMed Reference 22940748
Abstract The Mouse Metabolic Phenotyping Centers (MMPCs) were founded in 2001 by the
National Institutes of Health (NIH) to advance biomedical research by providing
the scientific community with standardized, high-quality phenotyping services
for mouse models of diabetes, obesity, and their complications. The intent is to
allow researchers to take optimum advantage of the many new mouse models
produced in labs and in high-throughput public efforts. The six MMPCs are
located at universities around the country and perform complex metabolic tests
in intact mice and hormone and analyte assays in tissues on a fee-for-service
basis. Testing is subsidized by the NIH in order to reduce the barriers for
mouse researchers. Although data derived from these tests belong to the
researcher submitting mice or tissues, these data are archived after publication
in a public database run by the MMPC Coordinating and Bioinformatics Unit. It is
hoped that data from experiments performed in many mouse models of metabolic
diseases, using standard protocols, will be useful in understanding the nature
of these complex disorders. The current areas of expertise include energy
balance and body composition, insulin action and secretion, whole-body and
tissue carbohydrate and lipid metabolism, cardiovascular and renal function, and
metabolic pathway kinetics. In addition to providing services, the MMPC staff
provides expertise and advice to researchers, and works to develop and refine
test protocols to best meet the community's needs in light of current scientific
developments. Test technology is disseminated by publications and through annual
courses.




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