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Publication
Approach to assessing determinants of glucose homeostasis in the conscious
mouse.
Authors Hughey CC, Wasserman DH, Lee-Young RS, Lantier L
Submitted By David Wasserman on 8/25/2014
Status Published
Journal Mammalian genome : official journal of the International Mammalian Genome Society
Year 2014
Date Published
Volume : Pages 25 : 522 - 538
PubMed Reference 25074441
Abstract Obesity and type 2 diabetes lessen the quality of life of those afflicted and
place considerable burden on the healthcare system. Furthermore, the detrimental
impact of these pathologies is expected to persist or even worsen. Diabetes is
characterized by impaired insulin action and glucose homeostasis. This has led
to a rapid increase in the number of mouse models of metabolic disease being
used in the basic sciences to assist in facilitating a greater understanding of
the metabolic dysregulation associated with obesity and diabetes, the
identification of therapeutic targets, and the discovery of effective
treatments. This review briefly describes the most frequently utilized models of
metabolic disease. A presentation of standard methods and technologies on the
horizon for assessing metabolic phenotypes in mice, with particular emphasis on
glucose handling and energy balance, is provided. The article also addresses
issues related to study design, selection and execution of metabolic tests of
glucose metabolism, the presentation of data, and interpretation of results.




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