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High fat diet rescues disturbances to metabolic homeostasis and survival in the
Id2 null mouse in a sex-specific manner.
Authors Zhou P, Hummel AD, Pywell CM, Charlie Dong X, Duffield GE
Submitted By Giles Duffield on 10/30/2014
Status Published
Journal Biochemical and biophysical research communications
Year 2014
Date Published
Volume : Pages 451 : 374 - 381
PubMed Reference 25108156
Abstract Inhibitor of DNA binding 2 (ID2) is a helix-loop-helix transcriptional repressor
rhythmically expressed in many adult tissues. Our previous studies have
demonstrated that Id2 null mice have altered expression of circadian genes
involved in lipid metabolism, altered circadian feeding behavior, and
sex-specific enhancement of insulin sensitivity and elevated glucose uptake in
skeletal muscle and brown adipose tissue. Here we further characterized the
Id2-/- mouse metabolic phenotype in a sex-specific context and under low and
high fat diets, and examined metabolic and endocrine parameters associated with
lipid and glucose metabolism. Under the low-fat diet Id2-/- mice showed
decreased weight gain, reduced gonadal fat mass, and a lower survival rate.
Under the high-fat diet, body weight and gonadal fat gain of Id2-/- male mice
was comparable to control mice and survival rate improved markedly. Furthermore,
the high-fat diet treated Id2-/- male mice lost the enhanced glucose tolerance
feature observed in the other Id2-/- groups, and there was a sex-specific
difference in white adipose tissue storage of Id2-/- mice. Additionally, a
distinct pattern of hepatic lipid accumulation was observed in Id2-/- males: low
lipids on the low-fat diet and steatosis on the high-fat diet. In summary, these
data provides valuable insights into the impact of Id2 deficiency on metabolic
homeostasis of mice in a sex-specific manner.



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