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Publication
Ube3a imprinting impairs circadian robustness in angelman syndrome models.
Authors Shi SQ, Bichell TJ, Ihrie RA, Johnson CH
Submitted By Carl Johnson on 3/9/2015
Status Published
Journal Current biology : CB
Year 2015
Date Published
Volume : Pages 25 : 537 - 545
PubMed Reference 25660546
Abstract The paternal allele of Ube3a is silenced by imprinting in neurons, and Angelman
syndrome (AS) is a disorder arising from a deletion or mutation of the maternal
Ube3a allele, which thereby eliminates Ube3a neuronal expression. Sleep
disorders such as short sleep duration and increased sleep onset latency are
very common in AS.




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