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Obesity Alters B Cell and Macrophage Populations in Brown Adipose Tissue.
Peterson KR, Flaherty DK, Hasty AH
Submitted Externally on 11/9/2017
Obesity (Silver Spring, Md.)
Volume : Pages
25 : 1881 - 1884
The prevalence of obesity continues to rise, and it is understood that
regulation of white adipose tissue (WAT) function is important to systemic
metabolic homeostasis. Immune cells play a central role in the maintenance of
WAT, and their compositions change in number and inflammatory phenotype with the
progression of obesity. Because of its energy-burning capabilities, brown
adipose tissue (BAT) has become a focus of obesity research. Although novel
studies have focused on the function of brown adipocytes in thermogenesis, the
tissue as a whole has not been immunologically characterized., BAT immune cell
populations were analyzed by flow cytometry and immunohistochemistry in mice
with diet-induced obesity (3, 8, or 16 weeks of diet) and in aged mice (1, 6-7,
and 10-15 months)., The data confirmed the presence of macrophages and
eosinophils, as previously reported, and showed that 20% to 30% of the immune
cells in BAT were B cells. The number of B cells and eosinophils increased with
diet-induced obesity, whereas macrophages decreased. There was no change in
number of any immune cell quantified with age., These studies reveal a novel
finding of B220?+?B cells in BAT and show that BAT immune cell populations
change in response to diet-induced obesity.
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