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Publication
Standard operating procedures for describing and performing metabolic tests of
glucose homeostasis in mice.
Authors Ayala JE, Samuel VT, Morton GJ, Obici S, Croniger CM, Shulman GI, Wasserman DH,
McGuinness OP, for the NIH Mouse Metabolic Phenotyping Center Consortium
Submitted By Owen McGuinness on 8/31/2010
Status Published
Journal Disease models & mechanisms
Year 2010
Date Published 12/1/2010
Volume : Pages 3 : 525 - 534
PubMed Reference 20713647
Abstract The Mouse Metabolic Phenotyping Center (MMPC) Consortium was established to
address the need to characterize the growing number of mouse models of metabolic
diseases, particularly diabetes and obesity. A goal of the MMPC Consortium is to
propose standard methods for assessing metabolic phenotypes in mice. In this
article, we discuss issues pertaining to the design and performance of various
tests of glucose metabolism. We also propose guidelines for the description of
methods, presentation of data and interpretation of results. The recommendations
presented in this article are based on the experience of the MMPC Consortium and
other investigators.




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