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Publication
NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and
recommendations for evaluating glucose homeostasis in the mouse.
Authors McGuinness OP, Ayala JE, Laughlin MR, Wasserman DH
Submitted By Lynn Ulatowski on 12/20/2011
Status In press
Journal American journal of physiology. Endocrinology and metabolism
Year 2009
Date Published 10/1/2009
Volume : Pages 297 : E849 - E855
PubMed Reference 19638507
Abstract This article addresses two topics. We provide an overview of the National
Institutes of Health Mouse Metabolic Phenotyping Center (MMPC) Program. We then
discuss some observations we have made during the first eight years of the
Vanderbilt MMPC regarding common phenotyping practices. We include specific
recommendations to improve phenotyping practices for tests of glucose tolerance
and insulin action. We recommend that methods for experiments in vivo be
described in manuscripts. We make specific recommendations for data
presentation, interpretation, and experimental design for each test. To
facilitate and maximize the exchange of scientific information, we suggest that
guidelines be developed for methods used to assess glucose tolerance and insulin
action in vivo.




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