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Publication
Identification of body fat mass as a major determinant of metabolic rate in
mice.
Authors Kaiyala KJ, Morton GJ, Leroux BG, Ogimoto K, Wisse B, Schwartz MW
Submitted By Michael Schwartz on 12/20/2011
Status In press
Journal Diabetes
Year 2010
Date Published 7/1/2010
Volume : Pages 59 : 1657 - 1666
PubMed Reference 20413511
Abstract Analysis of energy expenditure (EE) in mice is essential to obesity research.
Since EE varies with body mass, comparisons between lean and obese mice are
confounded unless EE is normalized to account for body mass differences. We 1)
assessed the validity of ratio-based EE normalization involving division of EE
by either total body mass (TBM) or lean body mass (LBM), 2) compared the
independent contributions of LBM and fat mass (FM) to EE, and 3) investigated
whether leptin contributes to the link between FM and EE.




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