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Programming effects of maternal and gestational obesity on offspring metabolism
and metabolic inflammation.
Authors Chang E, Hafner H, Varghese M, Griffin C, Clemente J, Islam M, Carlson Z, Zhu A,
Hak L, Abrishami S, Gregg B, Singer K
Submitted By Submitted Externally on 11/24/2019
Status Published
Journal Scientific reports
Year 2019
Date Published 11/1/2019
Volume : Pages 9 : 16027
PubMed Reference 31690792
Abstract With the increasing prevalence of obesity in women of reproductive age there is
a need to understand the ramifications of this on offspring. The purpose of this
study is to investigate the programming effects of maternal obesity during
preconception and the preconception/gestational period on adiposity and adipose
tissue inflammation in offspring using an animal model. Adult female C57Bl/6J
mice were assigned either normal diet, high fat diet (HFD) prior to pregnancy,
or HFD prior to and through pregnancy. Some offspring were maintained on normal
diet while others started HFD later in life. Offspring were assessed for body
composition and metabolic responses. Lipid storing tissues were evaluated for
expansion and inflammation. Male offspring from the preconception group had the
greatest weight gain, most subcutaneous adipose tissue, and largest liver
mass when introduced to postnatal HFD. Male offspring of the
preconception/gestation group had worsened glucose tolerance and an increase in
resident (CD11c-) adipose tissue macrophages (ATMs) when exposed to postnatal
HFD. Female offspring had no significant difference in any parameter between the
diet treatment groups. In conclusion, this study demonstrates that prenatal and
pregnancy windows have independent programming effects on offspring.
Preconception exposure affects body composition and adiposity while gestation
exposure affects metabolism and tissue immune cell phenotypes.


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