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Strain
B6.129S2-Serpine1tm1Mlg/J

Summary Data Summary
Official Name B6.129S2-Serpine1tm1Mlg/J
Common Name PAI-1 -
Description A PGK-neomycin resistance cassette replaced all of the
Serpine1 coding sequence and part of the promoter region
including the transcription initiation site. Northern blot
analysis did not detect Serpine1 mRNA in endotoxin-treated
homozygous mutant liver. Neither untreated nor
endotoxin-treated homozygous mutant kidney produced
detectable SERPINE1 immunoreactivity. A monoclonal antibody
based immunofunctional assay did not detect protein levels
in plasma of endotoxin-treated homozygous mutant mice.
Creation Method knockout
TypeCount
Genomics - Modifications 1
Experiments 1
Publications 2


Genomic Information
GeneAllele 1Allele 2Protocol
Serpine1knockoutknockoutNot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1.
Ma LJ, Mao SL, Taylor KL, Kanjanabuch T, Guan Y, Zhang Y, Brown NJ, Swift LL, McGuinness OP, Wasserman DH, Vaughan DE, Fogo AB
Diabetes, 2004 (53), 336 - 346
14747283
Published
Bone marrow plasminogen activator inhibitor-1 influences the development of obesity.
De Taeye BM, Novitskaya T, Gleaves L, Covington JW, Vaughan DE
The Journal of biological chemistry, 2006 (281), 32796 - 32805
16931518
Published

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