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Strain
C57BL/6J-Notch1tm1Grid Foxo1tm1Whb

Summary Data Summary
Official Name C57BL/6J-Notch1tm1Grid Foxo1tm1Whb
Common Name C57BL/6J-Notch1+/- Foxo1+/-
Description Insertion of a neomycin cassette into an exon encoding EGF
repeat 32, disrupting the reading frame of the protein.

The endogenous locus was disrupted by a beta-geo cassette
inserted immediately downstream of the start codon in exon 1
by homologous recombination. The deleted region included the
coding region of exon 1 and approximately 3 kb of intronic
sequnence. Transcript was undetected by RT-PCR analysis of
homozygous mutant embryos.
Development Status Phenotyping ongoing
Creation Method knockout
TypeCount
Investigators 1
Genomics - Modifications 2
Experiments 1


Investigators
NameInstitution
Domenico AcciliColumbia University


Genomic Information
GeneAllele 1Allele 2Protocol
Notch1knockoutknockoutNot Specified
Foxo1knockoutknockoutNot Specified


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