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Strain
C57BLKS-Tbc1d4tm1.2Arte

Summary Data Summary
Official Name C57BLKS-Tbc1d4tm1.2Arte
Common Name C57BLKS-Tbc1d4tm1.2Arte
Description TBC1 domain family, member 4 gene was knocked out in the
C57BLKS background.

Exon 10 was replaced with an FRT-flanked neo cassette with a
5' loxP site and a modified exon 10 in which nucleotide
substitutions result in the amino acid substitution of
alanine for threonine at position 649 (T649A) followed by a
loxP site. Flp-mediate recombination removed the neo
cassette. Cre-mediated recombination removed the modified
exon 10. Western blot analysis confirmed the absence of
protein expression in the soleus, gastrocnemius, tibialis
anterior, adipose and heart.
Development Status Phenotyping ongoing
Creation Method knockout
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1


Investigators
NameInstitution
Carol MacKintoshThe University of Dundee


Genomic Information
GeneAllele 1Allele 2Protocol
Tbc1d4knockoutknockoutNot Specified


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