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Strain
C57BL/6-Mc4rtm1Dhu/+

Summary Data Summary
Official Name C57BL/6-Mc4rtm1Dhu/+
Common Name C57BL/6-Mc4r-/+
Description Melanocortin 4 receptor (Mc4r) heterozygous knockout on the
C57BL/6 background

A neomycin selection cassette replaced all but the first 20
nucleotides of the coding region of Mc4r. Northern blot
analysis showed a lack of transcript in homozygous mice.
Development Status Phenotyping ongoing
Creation Method knockout
Background C57BL/6
Breeding Type backcross
Breeding Generations 20
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 3
Publications 1


Investigators
NameInstitution
Roger ConeOregon Health Sciences University


Genomic Information
GeneAllele 1Allele 2Protocol
Mc4rknockoutwildNot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Melanocortin-4 receptor mutations paradoxically reduce preference for palatable foods.
Panaro BL, Cone RD
Proceedings of the National Academy of Sciences of the United States of America, 2013 (110), 7050 - 5
Submitted Externally
23569235
Published

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