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Strain
B6.129X1-Nrf1tm1Hota Tg(Alb-cre)21Mgn

Summary Data Summary
Official Name B6.129X1-Nrf1tm1Hota Tg(Alb-cre)21Mgn
Common Name C57BL/6J-Tg(Alb-cre)21Mgn Nrf1lox/lox
Description This strain is a liver specific knockout of the Nrf1 gene. A
transgenic construct containing a 2.34 kbp mouse albumin
enhancer/promoter, nuclear localization sequence-modified
Cre recombinase and a 2.1 kbp fragment from the human growth
hormone gene was injected into B6D2(F2) pronuclei. These
mice were subsequently backcrossed to C57BL/6J mice. A
targeting construct containing a 5' loxP site inserted into
the nrf1 intron-3.
Development Status Phenotyping ongoing
TypeCount
Investigators 1
Genomics - Modifications 1
Genomics - Transgenes 1


Investigators
NameInstitution
Gokhan HotamisligilHarvard School of Public Health


Genomic Information
GeneAllele 1Allele 2Protocol
Nrf1knockin (lox)knockin (lox)Not Specified
EnhancerPromoterGeneCopies
Not SpecifiedAlbCRENot Specified

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