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Strain
C57BL/6J-Ucp1tm1Kz

Summary Data Summary
Official Name C57BL/6J-Ucp1tm1Kz
Common Name C57BL/6J-Ucp1-/-
Description Global knockout of uncoupling protein 1 (mitochondrial,
proton carrier), Ucp1.

All of exon 2 and a portion of exon 3 were replaced by a
neomycin selection cassette. The deleted region encoded an
essential transmembrane domain.
Development Status Phenotyping ongoing
Creation Method knockout
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1
Publications 1


Investigators
NameInstitution
Thomas W GettysPennington Biomedical Research Center


Genomic Information
GeneAllele 1Allele 2Protocol
Ucp1knockoutknockoutNot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
UCP1 is an essential mediator of the effects of methionine restriction on energy balance but not insulin sensitivity.
Wanders D, Burk DH, Cortez CC, Van NT, Stone KP, Baker M, Mendoza T, Mynatt RL, Gettys TW
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015 (29), 2603 - 2615
25742717
Published

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