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Strain
B6.129-Mapk9tm1.1Rjd/J

Summary Data Summary
Official Name B6.129-Mapk9tm1.1Rjd/J
Common Name B6.129-Jnk2tm1.1Rjd/J
Description In this strain, codon 108 in exon 6 of the endogenous
mitogen-activated protein kinase 9 (Mapk9 or c-Jun
N-terminal kinase 2 (Jnk2)) gene was mutated from a
Methionine (ATG) to a Glycine (GGG). Homozygous mice are
viable, fertile, and normal in size. Jnk2 exhibits
widespread expression and is involved in the regulation of
cellular proliferation, transformation, and apoptosis, and
has been implicated in some neurodegenerative diseases,
diabetes, and arthritis. Phosphorylation of JNK2 by other
MAPK kinases is required for activation. This mutation in
JNK2MG/MG mice expands the size of the ATP pocket of JNK2,
increasing sensitivity to inactive small molecule inhibition
by PP1, allowing for specific reversible JNK2 inhibition.
These mice exhibit a loss of JNK2 signaling while
maintaining expression, and show an increase in cellular
proliferation, motility, and survival. These mice may be
useful for studying MAP kinase signaling pathways, JNK
activation and regulation, and cellular growth.
Development Status Phenotyping ongoing
Creation Method knockout
Phenotype Description In this strain, codon 108 in exon 6 of the endogenous
mitogen-activated protein kinase 9 (Mapk9 or c-Jun
N-terminal kinase 2 (Jnk2)) gene was mutated from a
Methionine (ATG) to a Glycine (GGG). These mice may be
useful for studying MAP kinase signaling pathways, JNK
activation and regulation, and cellular growth.
TypeCount
Investigators 1
Genomics - Modifications 1


Investigators
NameInstitution
Roger J. DavisUniversity of Massachusetts Medical School


Genomic Information
GeneAllele 1Allele 2Protocol
Mapk9nucleotide subsitutionnucleotide subsitutionNot Specified

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