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Strain
NMRI-Prox1tm5(GFP/cre)Gco/+

Summary Data Summary
Official Name NMRI-Prox1tm5(GFP/cre)Gco/+
Common Name NMRI-Prox1tm5(GFP/cre)Gco/+
Description A GFPCre expression cassette was inserted into the
transcription start site (ATG) of the Prox1 genomic locus
along with a neomycin selection cassette. A thymidine kinase
negative-selection cassette was also included. The targeting
construct was electroporated into W9.5 mouse ES cells.
Following selection and screening via standard methods,
correctly targeted ES cell clones were used to generate the
chimeric mice.

The NMRI outbred model was developed by Lynch et al. Poiley
of the National Institutes of Health received stock from
Lynch in 1937. The mice were inbred as NIH/P1. The Naval
Medical Research Institute (NMRI) received stock from Lynch.
Zentralinstitut für Versuchstierzucht in Hannover Germany
(Han) received stock from NMRI. The mice were random bred.
M&B A/S (now Taconic Europe) received stock from Han in 1961
and again in 1985. The mice are maintained as an outbred
stock.
Development Status Phenotyping ongoing
Creation Method knockout
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1


Investigators
NameInstitution
Guillermo OliverSt. Jude Childrens Research Hospital


Genomic Information
GeneAllele 1Allele 2Protocol
Prox1knockoutwildNot Specified


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