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Strain
B6.Cg-Rab10tm1a(KOMP)Wtsi Tg(Adipoq-cre)

Summary Data Summary
Official Name B6.Cg-Rab10tm1a(KOMP)Wtsi Tg(Adipoq-cre)
Common Name C57BL/6J-Rab10tm1Vaz Tg(Adipoq-Cre)1Vaz
Description Embryonic stem cells containing a Rab10 conditional KO
construct (Knockout Mouse Project CSD44891) were
microinjected to generate chimera mice. Offspring with
the construct were crossed with Flipase transgenic mice to
remove the selection cassette and generate carriers of a
conditional Rab10 allele containing loxP sites flanking
exon 1 of Rab10. The colony was backcrossed to C57BL/6J
mice four times. Heterozygotes with (Rab10fl/wt + cre)
and without (Rab10fl/wt) the adiponectin-cre transgene
were bred to generate mice for the majority of experiments
Development Status Phenotyping ongoing
Creation Method knockin
TypeCount
Investigators 1
Genomics - Modifications 1
Genomics - Transgenes 1
Experiments 1
Publications 1


Investigators
NameInstitution
Reema VaziraniWeill Cornell Medical College


Genomic Information
GeneAllele 1Allele 2Protocol
Rab10knockin (lox)knockin (lox)Not Specified
EnhancerPromoterGeneCopies
Not SpecifiedAdipoqCRENot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance.
Vazirani RP, Verma A, Sadacca LA, Buckman MS, Picatoste B, Beg M, Torsitano C, Bruno JH, Patel RT, Simonyte K, Camporez JP, Moreira G, Falcone DJ, Accili D, Elemento O, Shulman GI, Kahn BB, McGraw TE
Diabetes, 2016 (65), 1577 - 89
Submitted Externally
27207531
Published

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