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Strain
FVB/N-Tg(Alb-Ppp1r15a)

Summary Data Summary
Official Name FVB/N-Tg(Alb-Ppp1r15a)
Common Name FVB/N-Tg(Alb-GADD34)
Description A 2.3 kb mouse albumin enhancer/promoter fragment was used
to drive expression of hamster GADD34 (aa 292–590) in the
transgene. Two transgenic lines, #14 and #16, were
established in the FVB/N strain. These lines exhibited
similar sensitivity to fasting hypoglycemia, and the
higher-expressing line, #14, was used in subsequent studies.
The gene encoding growth arrest and DNA damage inducible
protein 34 (GADD34), which is a transcription factor
involved in the unfolded protein response (UPR), was cloned
from CHO-K1 cells.
Development Status Phenotyping ongoing
Creation Method transgenic
Background FVB/N
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Transgenes 1
Experiments 2


Investigators
NameInstitution
Gerald I. ShulmanYale University


Genomic Information
EnhancerPromoterGeneCopies
Not SpecifiedAlbPpp1r15aNot Specified


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