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Strain
STOCK Ern1tm2.1Rjk Tg(Alb-Cre)21Mgn

Summary Data Summary
Official Name STOCK Ern1tm2.1Rjk Tg(Alb-Cre)21Mgn
Common Name C57BL/6-Ire1alox/lox Tg(Alb-Cre)
Description A loxP site was inserted upstream of Ern1 (Ire1a) exon 16. A
floxed neo cassette was inserted downstream of exon 17.
Cre-mediated recombination removed the neo cassette and left
exons 16 and 17 floxed.

Mice with one or two floxed Ire1a alleles were viable,
fertile, and apparently normal. Mice that harbour one floxed
Ire1a allele and one Ire1a-null allele (Ire1afe/-) were bred
with transgenic mice expressing Cre recombinase under the
control of the albumin promoter to obtain offspring with
hepatocyte-specific Ire1a deletion.
Development Status Phenotyping ongoing
Creation Method knockout
Background C57BL/6
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Genomics - Transgenes 1
Experiments 2
Publications 1


Investigators
NameInstitution
Randal KaufmanUniversity of Michigan-Ann Arbor


Genomic Information
GeneAllele 1Allele 2Protocol
Ern1knockin (lox)knockin (lox)Not Specified
EnhancerPromoterGeneCopies
Not SpecifiedAlbCRENot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
The unfolded protein response transducer IRE1a prevents ER stress-induced hepatic steatosis.
Zhang K, Wang S, Malhotra J, Hassler JR, Back SH, Wang G, Chang L, Xu W, Miao H, Leonardi R, Chen YE, Jackowski S, Kaufman RJ
The EMBO journal, 2011 (30), 1357 - 75
Submitted Externally
21407177
Published

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