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Strain
B6.Cg-Sptlc2tm1Jia Lyz2tm1(cre)Ifo

Summary Data Summary
Official Name B6.Cg-Sptlc2tm1Jia Lyz2tm1(cre)Ifo
Common Name C57BL/6-Sptlc2tm1Jia Lyz2tm1(cre)Ifo
Description A loxP site was inserted upstream of Sptlc2 exon 1 and an
frt flanked neo cassette with a 5' loxP site was inserted
downstream of exon 1. Flp mediated recombination removed the
neo cassette leaving exon 1 floxed.

An NLS-cre gene was inserted into the endogenous ATG start
site of the Lyz2. An frt-flanked neomycin cassette was
removed in ES cells via Flp-mediated recombination prior to
production of chimeric mice.
Development Status Phenotyping ongoing
Creation Method knockout
Background C57BL/6
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 2
Experiments 2
Publications 1


Investigators
NameInstitution
Vishwa DixitYale University


Genomic Information
GeneAllele 1Allele 2Protocol
Sptlc2knockin (lox)knockin (lox)Not Specified
Lyz2knockin (Cre)knockin (Cre)Not Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Macrophage-specific de Novo Synthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity.
Camell CD, Nguyen KY, Jurczak MJ, Christian BE, Shulman GI, Shadel GS, Dixit VD
The Journal of biological chemistry, 2015 (290), 29402 - 13
Submitted Externally
26438821
Published

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