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Strain
C57BL/6-Ppargtm1.1Gonz Tg(Tek-Cre)1Ywa

Summary Data Summary
Official Name C57BL/6-Ppargtm1.1Gonz Tg(Tek-Cre)1Ywa
Common Name C57BL/6-Ppargtm1.1Gonz Tg(Tie2-Cre)
Description PPAR?-floxed and Tie2Cre mice described, are of mixed
C57BL6/N;Sv129;FVB/N background. Using sibling matings
(?EC/BM-KO males and ?EC/BM-WT females), mice were bred for
at least 12 generations.

Pparg knockin: Animals heterozygous for Ppargtm1Gonz were
crossed to an EIIa-cre transgenic line to delete the floxed
PGK-neo cassette. The deletion event leaves behind single
loxP sites flanking exon 2. Southern blot analysis confirmed
the removal of PGK-neo in offspring.
Development Status Phenotyping ongoing
Creation Method knockout
Breeding Type intercross
Breeding Generations 12
TypeCount
Investigators 1
Genomics - Modifications 1
Genomics - Transgenes 1
Experiments 1


Investigators
NameInstitution
Gerald I. ShulmanYale University


Genomic Information
GeneAllele 1Allele 2Protocol
Ppargknockin (lox)knockin (lox)Not Specified
EnhancerPromoterGeneCopies
Not SpecifiedTekCRENot Specified


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