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Strain
B6.129S7-Il1r1tm1Imx/J

Summary Data Summary
Official Name B6.129S7-Il1r1tm1Imx/J
Common Name B6.129S7-Il1r1tm1Imx/J
Description A null mutation in Il1r1 was generated by homologous
recombination in 129/SvEv AB1 ES cells using a replacement
vector in which a 2.4 kb EcoR1-Pst1 fragment encompassing
two exons was replaced with a PGKneo cassette. Targeted
mutant mice were backcrossed 5 times to C57BL/6 prior to
importation.
Development Status Phenotyping ongoing
Creation Method knockout
Breeding Type intercross
Phenotype Description Interleukin 1 receptor, type I, is a receptor for
interleukin 1 (IL1), which affects many cytokine induced
immune and inflammatory responses. Mice homozygous for the
Il1r targeted mutation therefore fail to respond to
IL1 and exhibit an altered immune response to many different
target proteins. Some effects seen from knocking out this
receptor include defective responses to certain inflammatory
agents such as turpentine and altered response to various
pathogenic organisms such as S. aureus and C. pneumoniae.
Other observed effects include enhanced glucose homeostasis,
enhanced insulin sensitivity of adipose tissue, reduction in
diet-induced systemic atherosclerosis, improved restoration
of normal skin architecture in wounds, increased incidence
of acute convulsive seizures induced by pentylenetetrazole,
and a decrease in anxiety-related behaviors.
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1


Investigators
NameInstitution
Gerald I. ShulmanYale University


Genomic Information
GeneAllele 1Allele 2Protocol
Il1r1knockoutknockoutNot Specified


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