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Strain
C57BL/6-Hprttm8(Tek-IGF1R*K1003)#Vis

Summary Data Summary
Official Name C57BL/6-Hprttm8(Tek-IGF1R*K1003)#Vis
Common Name C57BL/6-Hprttm8(Tek-IGF1R*K1003)
Description To allow the role of the type I human insulin-like growth
factor receptor to be further investigated in vivo, a mouse
model was generated, expressing the type I human
insulin-like growth factor receptor cDNA with a mutation at
the ATP-binding site, lysine K1003 (hIGF·IR K1003). The
hIGF·IR K1003 cDNA has been placed under the control of the
Tek promoter to direct endothelial specific transgene
expression. The hIGF·IR K1003 transgene under the control of
the Tek promoter was introduced into the Hprt locus by
homologous recombination.
Development Status Phenotyping ongoing
Creation Method knockin
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Genomics - Transgenes 1
Experiments 1


Investigators
NameInstitution
Hema ViswambharanLeeds Institute of Genetics, Health and Therapeutics


Genomic Information
GeneAllele 1Allele 2Protocol
HprtknockinknockinNot Specified
EnhancerPromoterGeneCopies
Not SpecifiedTekIGF1RNot Specified


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