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Strain
FVB.129P2-Abcb4tm1Bor/J

Summary Data Summary
Official Name FVB.129P2-Abcb4tm1Bor/J
Common Name FVB.129P2-Abcb4tm1Bor/J
Description A neomycin selection cassette replaced a genomic fragment
containing exons 1 and 2. The translation initiation site is
in exon 2. RNase proteiction assays indicated that mutant
truncated transcripts are produced from this allele that
contain exons 3-6 or 4-6.
Development Status Phenotyping ongoing
Creation Method knockout
Breeding Type intercross
Phenotype Description Mice homozygous for the Abcb4tm1Bor mutation lack the
ability to secrete phospholipid into the bile from the
liver. They develop a degenerative liver disease. Portal
inflammation ensues at an early age followed by
hepatocellular carcinoma development after the age of 1
year. Bile from heterozygous mice has half the level of
phospholipid when compared to bile from homozygotes. No
liver pathology has been shown in heterozygotes.
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 6
Publications 1


Investigators
NameInstitution
SHI-YING CAIYale University


Genomic Information
GeneAllele 1Allele 2Protocol
Abcb4knockoutknockoutNot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Altered expression and function of canalicular transporters during early development of cholestatic liver injury in Abcb4-deficient mice.
Cai SY, Mennone A, Soroka CJ, Boyer JL
American journal of physiology. Gastrointestinal and liver physiology, 2014 (306), G670 - 6
Submitted Externally
24481602
Published

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