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Strain
B6;129P2-Pnpla2tm1Rze/J

Summary Data Summary
Official Name B6;129P2-Pnpla2tm1Rze/J
Common Name ATGL-/-
Description A neomycin resistance cassette replaced the first exon
including the translational start codon and the lipase
consensus sequence motif (GXSXG). Northern analysis of white
adipose tissue did not detect transcript in white adipose
tissue from homozygous mutant mice. Similarly, western blot
analysis of white adipose tissue from homozygous mutant mice
did not detect protein.
Development Status Phenotyping ongoing
Creation Method knockout
Phenotype Description Homozygotes exhibit a shortened lifespan, abnormal lipid
homeostasis, glucose tolerance, and cardiovascular
physiology and have applications in studies of impaired
cardiac function, thermogenesis and lipid and energy
homeostasis.
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 2


Investigators
NameInstitution
Monica LeeYale University


Genomic Information
GeneAllele 1Allele 2Protocol
Pnpla2knockoutknockoutNot Specified


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