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Strain
C57BL/6-Hkdc1tm1a(KOMP)Wtsi

Summary Data Summary
Official Name C57BL/6-Hkdc1tm1a(KOMP)Wtsi
Common Name HKDC1 KO
Description The L1L2_Bact_P cassette was inserted at position 62412339
of Chromosome 10 upstream of the critical exon(s) (Build
GRCm38). The cassette is composed of an FRT site followed by
lacZ sequence and a loxP site. This first loxP site is
followed by neomycin under the control of the human
beta-actin promoter, SV40 polyA, a second FRT site and a
second loxP site. A third loxP site is inserted downstream
of the targeted exon(s) at position 62411224. The critical
exon(s) is/are thus flanked by loxP sites. A "conditional
ready" (floxed) allele can be created by flp recombinase
expression in mice carrying this allele. Subsequent cre
expression results in a knockout mouse. If cre expression
occurs without flp expression, a reporter knockout mouse
will be created.
Development Status Phenotyping ongoing
Creation Method knockout
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 2
Publications 1


Investigators
NameInstitution
Anton LudvikNorthwestern University


Genomic Information
GeneAllele 1Allele 2Protocol
Hkdc1knockoutknockoutNot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
HKDC1 Is a Novel Hexokinase Involved in Whole-Body Glucose Use.
Ludvik AE, Pusec CM, Priyadarshini M, Angueira AR, Guo C, Lo A, Hershenhouse KS, Yang GY, Ding X, Reddy TE, Lowe WL, Layden BT
Endocrinology, 2016 (157), 3452 - 61
Submitted Externally
27459389
Published

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