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Strain
C57BL/6-Ghsrtm1Rgs

Summary Data Summary
Official Name C57BL/6-Ghsrtm1Rgs
Common Name Ghsr-/-
Description The entire coding region of exon 1 and part of the coding
region of exon 2 were replaced with a pGKneo cassette via
homologous recombination. RT-PCR demonstrated lack of mRNA
in homozygous mutant pituitary glands.
Development Status Phenotyping ongoing
Creation Method knockout
Phenotype Description GHSR null mice have improved insulin sensitivity
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1
Publications 2


Investigators
NameInstitution
Yuxiang SunTexas A & M University System Health Science Center


Genomic Information
GeneAllele 1Allele 2Protocol
GhsrknockoutknockoutNot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues.
Lin L, Saha PK, Ma X, Henshaw IO, Shao L, Chang BH, Buras ED, Tong Q, Chan L, McGuinness OP, Sun Y
Aging cell, 2011 (10), 996 - 1010
21895961
Published
Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice.
Ma X, Lin Y, Lin L, Qin G, Pereira FA, Haymond MW, Butte NF, Sun Y
American journal of physiology. Endocrinology and metabolism, 2012 (303), E422 - E431
22669248
Published

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