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Strain
B6.Cg-Pkd1tm2Som Tg(Pkhd1-cre)1Igr

Summary Data Summary
Official Name B6.Cg-Pkd1tm2Som Tg(Pkhd1-cre)1Igr
Common Name Pkd1fl/fl;Pkhd1-Cre
Description Pkd1 flox: An frt-flanked neo cassette with a 5' loxP site
was inserted downstream of exon 4 and an additional loxP was
inserted upstream of exon 2. Germ line, flp-mediated
recombination was used to remove the neo cassette and leave
exons 2 to 4 floxed.

Tg: 2 Kb of the mouse Pkhd1 promoter was used to drive the
expression of a nuclear-locatized cre gene followed by a
metallothionein-1 polyadenylation sequence. No line
information was given.
Development Status Phenotyping ongoing
Creation Method knockout
Breeding Type intercross
TypeCount
Investigators 1
Genomics - Modifications 1
Genomics - Transgenes 1
Experiments 3
Publications 1


Investigators
NameInstitution
Xin TianYale University


Genomic Information
GeneAllele 1Allele 2Protocol
Pkd1knockin (lox)knockin (lox)Not Specified
EnhancerPromoterGeneCopies
Not SpecifiedPkhd1CRENot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease.
Ma M, Tian X, Igarashi P, Pazour GJ, Somlo S
Nature genetics, 2013 (45), 1004 - 12
Submitted Externally
23892607
Published

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