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Strain
B6.Cg-Pkhd1tm1Som

Summary Data Summary
Official Name B6.Cg-Pkhd1tm1Som
Common Name Pkhd1del4
Description A 0.8 kb fragment, which contains part of exon 4 that
encodes the terminal 46 amino acids and part of intron 4,
was replaced with a neo cassette. The presence of two
truncated transcripts (one lacking part of exon 4 and exon
5, and the other lacking all of exon 4) was confirmd by
RT-PCR analysis on kindey and liver extracts.
Development Status Phenotyping ongoing
Creation Method knockout
Phenotype Description mice develop intrahepatic bile duct proliferation with
progressive cyst formation and associated periportal
fibrosis
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1


Investigators
NameInstitution
Seung LeeYale University


Genomic Information
GeneAllele 1Allele 2Protocol
Pkhd1knockoutknockoutNot Specified


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