mmpc-logo mmpc-logo
twitter-logo    bluesky-logo
| Create Account | login
Strain
B6.129S4-Ccl2tm1Rol/J

Summary Data Summary
Official Name B6.129S4-Ccl2tm1Rol/J
Common Name Ccl2 KO
Description A small deletion and an in frame stop codon were created in
exon 1. A PGK-neomycin resistance cassette was also inserted
into exon 2. Secreted protein was not detected in stimulated
peritoneal macrophages from homozygous mutant mice.
Development Status Phenotyping ongoing
Creation Method knockout
Phenotype Description Mice that are homozygous for the targeted mutation show
similar numbers of peritoneal macrophages, Kupffer cell and
alveolar macrophages to those observed in wildtype mice.
Thioglycollate induced peritonitis results in impaired
recruitment of monocytes and macrophages to peritoneal
cavity. Cellular recruitment to delayed-type
hypersensitivity challenges and secondary granulomata is
reduced. This mutant mouse strain represents a model that
may be useful in studies related to leukocyte trafficking.
TypeCount
Genomics - Modifications 1
Experiments 1


Genomic Information
GeneAllele 1Allele 2Protocol
Ccl2knockoutknockoutNot Specified


Menu

Home
Contact
About MMPC
Animal Husbandry
Tests Data
Search Data
Analysis
Clients
MMPC Centers

Newsletter

Interested in receiving MMPC News?
twitter-logo Mouse Phenotyping
@NationalMMPC



2017 National MMPC. All Rights Reserved.