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Strain
B6N.129S-Pnpla2tm1Eek/J

Summary Data Summary
Official Name B6N.129S-Pnpla2tm1Eek/J
Common Name ATGL fl/fl
Description The Pbpla2 gene was flanked with loxP sites.

The Pnpla2 gene encodes for the adipose triglyceride lipase
enzyme that catalyzes the first step in triglyceride
hydrolysis.These mice possess loxP sites on either side of
exons 2 through 7 of the Pnpla2 gene. Mice that are
homozygous for this allele are viable and fertile. When
these mutant mice are bred to mice that express Cre
recombinase, resulting offspring will have exons 2 through 7
deleted in the cre-expressing tissues, resulting in loss or
significant reduction of ATGL-mediated triacyglycerol
hydrolysis in the tissues where Cre recombinase is
expressed.
Development Status Phenotyping ongoing
Creation Method knockin
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1


Investigators
NameInstitution
Monica LeeYale University


Genomic Information
GeneAllele 1Allele 2Protocol
Pnpla2knockin (lox)knockin (lox)Not Specified


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