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Strain
B6.129X1-Prkacatm3Gsm

Summary Data Summary
Official Name B6.129X1-Prkacatm3Gsm
Common Name Prkaca KO
Description A W196R mutation was introduced into exon 7 by homolgous
recombination. A loxP flanked neomycin resistance gene
containing the SV40 polyA sequence was inserted into intron
5. Western blot demonstrated that mutant cells express half
of the level of protein as that of wild-type cells.
Cre-mediated recombination restores the expression of the
mutant transcript containing the point mutation, and
expression of the mutant protein.
Development Status Phenotyping ongoing
Creation Method knockout
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1
Publications 1


Investigators
NameInstitution
Barton WicksteedUniversity of Chicago


Genomic Information
GeneAllele 1Allele 2Protocol
PrkacaknockoutknockoutNot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
ß-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion.
Kaihara KA, Dickson LM, Jacobson DA, Tamarina N, Roe MW, Philipson LH, Wicksteed B
Diabetes, 2013 (62), 1527 - 36
Submitted Externally
23349500
Published

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