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Strain
B6.129S-Cd74tm1Liz/J

Summary Data Summary
Official Name B6.129S-Cd74tm1Liz/J
Common Name Cd74 KO
Description A MC1neopA cassette replaced the first intron and 11
nucleotides of the second exon.
Development Status Phenotyping ongoing
Creation Method knockout
Phenotype Description Mice homozygous for the Iitm1Liz targeted mutation are
viable and fertile. Ia-associated invariant chain deficient
mice have defects in MHC Class II assembly, transport,
surface expression, and antigen presentation. Homozygous
mutant mice lack mature CD4+ cells.
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 1


Investigators
NameInstitution
David AssisYale University


Genomic Information
GeneAllele 1Allele 2Protocol
Cd74knockoutknockoutNot Specified


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