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Strain
B6.SJL-Pkd1tm1Som/+ Pkd2tm2Som/+

Summary Data Summary
Official Name B6.SJL-Pkd1tm1Som/+ Pkd2tm2Som/+
Common Name Pkd1tm1Som/+ Pkd2tm2Som/+
Description Pkd1 KO: A neo cassette was inserted immediately downstream
of the initiation methionine codon. The absence of
transcript was confirmed by RT-PCR on E13.5 kidney extracts.

Pkd2 KO: Exon 1 was disrupted by the insertion of a
selectable Neo cassette in the same transcriptional
orientation as the gene. This allele is a a presumed true
null as opposed to WS25 which is an apparent hypomorphic
allele.
Development Status Phenotyping ongoing
Creation Method knockout
Phenotype Description more prone to liver and kidney cysts than wild-type mice or
either heterozygote alone
TypeCount
Investigators 1
Genomics - Modifications 2
Experiments 1


Investigators
NameInstitution
Xin TianYale University


Genomic Information
GeneAllele 1Allele 2Protocol
Pkd1knockoutwildNot Specified
Pkd2knockoutwildNot Specified


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