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Strain
C57BL/6-Inppl1tm2.1Ssch/+ Tg(Tek-cre)1Ywa

Summary Data Summary
Official Name C57BL/6-Inppl1tm2.1Ssch/+ Tg(Tek-cre)1Ywa
Common Name ECSHIP2-/+
Description Mice with endothelium-specific deletion of the SHIP2
catalytic domain (ECSHIP2/+) were generated by crossing mice
with LoxP sites flanking exons 18–19 of the Inppl gene with
Tie2-Cre mice.
Development Status Phenotyping ongoing
Creation Method knockout
TypeCount
Investigators 1
Genomics - Modifications 1
Genomics - Transgenes 1
Experiments 1
Publications 1


Investigators
NameInstitution
Stephen WheatcroftLeeds Institute of Genetics, Health and Therapeutics


Genomic Information
GeneAllele 1Allele 2Protocol
Inppl1knockin (lox)wildNot Specified
EnhancerPromoterGeneCopies
Not SpecifiedTekCRENot Specified






PublicationAltmetricsSubmitted ByPubMed IDStatus
Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction, and Systemic Insulin Resistance.
Watt NT, Gage MC, Patel PA, Viswambharan H, Sukumar P, Galloway S, Yuldasheva NY, Imrie H, Walker AMN, Griffin KJ, Makava N, Skromna A, Bridge K, Beech DJ, Schurmans S, Wheatcroft SB, Kearney MT, Cubbon RM
Diabetes, 2017 (66), 2808 - 2821
Submitted Externally
28830894
Published

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