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Strain
C57BL/6-Tg(Pten)GPpp

Summary Data Summary
Official Name C57BL/6-Tg(Pten)GPpp
Common Name Tg(Pten)GPpp
Description The transgene comprises the 218.50-kb mouse genomic DNA
insert of the bacterial artificial chromosome (BAC) clone
RP23-215F15 (RPCI library; C57BL/6J), which contains the
entire phosphatase and tensin homolog (Pten) gene.
Immunoblot analysis of whole-cell protein extracts from
mouse embryonic fibroblasts (MEFs) cultured from E13.5
embryos of this line shows that they express the protein at
3.5-fold the level of wild-type MEFs; elevated levels are
observed in both cytoplasmic and nuclear MEF extracts.
Elevated PTEN protein expression is observed in embryos and
in all adult tissues analyzed: brain, lung, kidney, heart,
thymus, liver, spleen, and white and brown adipose tissue.
Development Status Phenotyping ongoing
Creation Method transgenic
TypeCount
Investigators 1
Genomics - Transgenes 1
Experiments 1


Investigators
NameInstitution
Sizhao LuUniversity of Colorado at Denver and Health Sciences Center


Genomic Information
EnhancerPromoterGeneCopies
Not SpecifiedNot SpecifiedPtenNot Specified


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