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Strain
B6.129(Cg)-Mfn1tm2Dcc/J

Summary Data Summary
Official Name B6.129(Cg)-Mfn1tm2Dcc/J
Common Name B6.129(Cg)-Mfn1tm2Dcc/J
Description FRT-flanked neo cassette followed by two loxP sites flanking
the exon 4 encoding the canonical G-1 GTPase motif replaced
the endogenous locus. The neo cassette was removed by
crossing with FLP recombinase expressing mice.

Mfn1loxP floxed mice possess loxP sites flanking exon 4 of
the mitofusin 1 (Mfn1) gene. Mitofusin 1 encodes a
transmembrane GTPase which mediates mitochondrial fusion.
Mice that are homozygous for this allele are viable and
fertile. When these mutant mice are bred to mice that
express Cre in a wide-spread manner, embryos die
mid-gestation due to placental defects. When bred to mice
that express tissue-specific Cre recombinase, resulting
offspring will have exon 4 deleted in the cre-expressing
tissues.
Development Status Phenotyping ongoing
Creation Method knockin
TypeCount
Investigators 1
Genomics - Modifications 1
Experiments 3


Investigators
NameInstitution
Muhammed Burak BenerYale University


Genomic Information
GeneAllele 1Allele 2Protocol
Mfn1knockin (lox)knockin (lox)Not Specified


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