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Strain
C57BL/6-Zfp36tm1.1Xen Tg(Alb-cre)21Mgn

Summary Data Summary
Official Name C57BL/6-Zfp36tm1.1Xen Tg(Alb-cre)21Mgn
Common Name Liver-Specific TTP KO
Description Zfp36 (aka TTP) fl/fl: A floxed neo cassette was inserted
upstream of the exon 2. An additional loxP site was inserted
downstream of the exon 2. Cre-mediated recombination removed
the neo cassette and left exon 2 floxed.

Transgene: The transgene contains a 2.34 kb mouse albumin
enhancer/promoter, a nuclear localization sequence-modified
Cre recombinase gene and a 2.1 kb fragment from the human
growth hormone gene. The promoter is active in hepatocyte
cells of the liver. 7 copies of the transgene are estimated
to be present. Line 21 inserted into the gene at
3172116-3172120 (Build GRCm38/mm10) resulting in a 4 bp
deletion.
Development Status Phenotyping ongoing
Creation Method transgenic
Phenotype Description Increased glucose tolerance, insulin sensitivity after high
fat diet.
TypeCount
Investigators 1
Genomics - Modifications 1
Genomics - Transgenes 1
Experiments 1


Investigators
NameInstitution
Jimmy ChangNorthwestern University Medical School


Genomic Information
GeneAllele 1Allele 2Protocol
Zfp36knockin (lox)knockin (lox)Not Specified
EnhancerPromoterGeneCopies
Not SpecifiedAlbCRENot Specified


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