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Strain
NOD/ShiLtJ

Summary Data Summary
Official Name NOD/ShiLtJ
Common Name NOD
Description The NOD/ShiLtJ strain (commonly called NOD) is a polygenic
model for autoimmune type 1 diabetes. Diabetes in NOD mice
is characterized by hyperglycemia and insulitis, a
leukocytic infiltration of the pancreatic islets. Marked
decreases in pancreatic insulin content occur in females at
about 12 weeks of age and several weeks later in males. A
2017 phenotyping study found that 90% of females and 52% of
males became diabetic by 30 weeks; median female incidence
was 18 weeks. Immune phenotypes in the NOD background
consist of defects in antigen presentation, T lymphocyte
repertoire, NK cell function, macrophage cytokine
production, wound healing, and C5 complement. These defects
make the NOD background a common choice for immunodeficient
mouse strains.
Development Status Not specified/Other
TypeCount

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