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Strain
C57BL/6-Tfebtm1a(EUCOMM)WtsiTg(Lyz2-cre)1Hlu/J

Summary Data Summary
Official Name C57BL/6-Tfebtm1a(EUCOMM)WtsiTg(Lyz2-cre)1Hlu/J
Common Name C57BL/6-Tfebtm1a(EUCOMM)WtsiTg(Lyz2-cre)1Hlu/J
Description The L1L2_Bact_P cassette was inserted at position 48098212
of Chromosome 17 upstream of the critical exon(s) (Build
GRCm39). The cassette is composed of an FRT site followed by
lacZ sequence and a loxP site. This first loxP site is
followed by a neomycin resistance gene under the control of
the human beta-actin promoter, SV40 polyA, a second FRT site
and a second loxP site. A third loxP site is inserted
downstream of the targeted exon(s) at position 48099451. The
critical exon(s) is/are thus flanked by loxP sites. A
"conditional ready" (floxed) allele can be created by flp
recombinase expression in mice carrying this allele.
Subsequent cre expression results in a knockout mouse.
Macrophage deficiency of transcription factor EB influence
whole body metabolism
Development Status Phenotyping ongoing
Creation Method knockout
TypeCount
Investigators 1
Genomics - Transgenes 1
Experiments 2


Investigators
NameInstitution
Haocheng LuUniversity of Michigan-Ann Arbor


Genomic Information
EnhancerPromoterGeneCopies
Not SpecifiedLyz2CRENot Specified


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