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Center Core
Diabetes and Energy Balance Core

Center University of Washington, Seattle
Website http://depts.washington.edu/mmpc/services/diabetes.html
Description Description of Services
* Precise, non-invasive, quantitative assessment of energy homeostasis in rodent
models including energy expenditure, respiratory quotient, locomotor activity,
body temperature, food intake, meal patterns and body composition.

* Assessment of a variety of metabolic disease phenotypes associated with
obesity and type 2 diabetes such as glucose intolerance, insulin resistance and
hyperlipidemia in mice.

* Quantification of the extent of insulitis and other inflammatory parameters in
mouse models of type 1 diabetes mellitus such as autoimmune NOD and
hyperglycemic Akita mice and mice treated with pancreatic islet toxins.

* Quantification using PCR approaches of the expression of genes in the
hypothalamus and other sites involved in food intake, energy expenditure, and
tissue complications of diabetes.

* Quantification of circulating and/or tissue factors (e.g. hormones, proteins,
lipids, and carbohydrates) associated with the metabolic syndrome, obesity, type
1 diabetes, or type 2 diabetes.

* Longitudinal studies: To perform longitudinal studies in single animals as a
function of age, diet or special treatment regimes using specific drugs or islet
toxins.
Is Subcore? No
Is Inactive? No


 Members
NameInstitutionEmailTitle
Michael SchwartzUniversity of Washingtonmschwart@u.washington.eduDirector
Gregory MortonUniversity of Washingtongjmorton@u.washington.eduCo-Director
Oanh MaiUniversity of Washingtonoanh98@u.washington.eduPersonnel

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