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Center Core
Rogers NMR Center Metabolic Core

Center University of Texas Southwestern Medical Center
Website http://www4.utsouthwestern.edu/rogersnmr/mousepheno_metab.htm
Description The Rogers NMR Center Mouse Metabolic Phenotyping Center specializes in the use
of stable isotopes for investigations of metabolism, including a comprehensive
analysis of gluconeogenesis. Our goal is to provide a repertoire of metabolic
analyses that can be standardized and used to phenotype mouse models of type 2
diabetes. These tools are based on new concepts for probing intermediary
metabolism using 13C- or 2H-enriched compounds. In some instances the studies
are simple enough to perform in the referring investigator's lab; only partially
processed tissue samples need be shipped to the Rogers NMR Center for full
analysis. Procedures are available for determining the substrates contributing
to plasma glucose, measurement of both the relative and absolute rates of the
pathways involved in gluconeogenesis, substrate utilization in the heart, and
23Na/31P NMR investigations of liver metabolism. In addition, software is made
available to predict the potential effects of genetic manipulation on various
pathways.
Is Subcore? No
Is Inactive? No


 Members
NameInstitutionEmailTitle
Shawn BurgessUniversity of Texas Southwesternshawn.burgess@utsouthwestern.eduCo-Director
Craig MalloyUniversity of Texas Southwesterncraig.malloy@utsouthwestern.eduDirector

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