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Center Core
Metabolic Core

Center Case Western Reserve University
Website http://www.case.edu/med/mmpc/
Description The Metabolic Core conducts in vivo and ex vivo metabolic experiments on mice
shipped to the Case MMPC. This core focuses on the following techniques and
measurements:
1) Chronic or acute arterial, jugular and/or gastric catheterization
2) Acute catheterization of portal vein or urinary bladder
3) Energy expenditure integrated over four days by the "doubly-labeled water"
method
4) Rates of fatty acid, cholesterol, triglycerides, or protein synthesis
measured using 2H2O
5) Insulin clamp, pancreatic clamp
6) Food intake
7) Body temperature
8) Urine and blood chemistry analysis
9) Glycosylated hemoglobin
10) Liver perfusion and heart perfusion
11) Tissue perfusion and fixation
Is Subcore? No
Is Inactive? No


 Members
NameInstitutionEmailTitle
Colleen CronigerCase Western Reservecolleen.croniger@case.eduDirector
Michelle PuchowiczThe University of Tennessee Health Science Centermpuchowi@uthsc.eduAssociate Director

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