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Center Core
Endocrinology and Metabolism Core

Center University of California Davis
Description The Endocrinology and Metabolism Core provides phenotyping services for the
assessment of endocrine function and metabolic pathways in mouse models of
obesity, diabetes, and related metabolic diseases including dyslipidemia and
fatty liver disease (NAFLD).

The Core also provides expertise, technical resources, and instrumentation
necessary to characterize perturbations in endocrine systems and metabolism in
murine models useful for understanding obesity, diabetes, its complications, and
related metabolic disorders, including NAFLD.

The Core performs assays and data interpretation for in vivo metabolic function
tests, including IV, IP and oral glucose tolerance tests and insulin tolerance
tests for parameters of insulin sensitivity, insulin secretion and glucose

In addition, the Core offers an extensive list of quality controlled assays of
metabolic substrates, endocrine hormones, and indices of renal function,
assessments of insulin signaling pathways, inflammation and endoplasmic
reticulum stress in metabolically important tissues such as liver, muscle,
adipose, pancreas, as well as state-of-the-art metabolomic analysis and
interpretation, including complex lipids, phospholipids, bile acids, and
biogenic amines using small sample volumes. The Core works closely with the
Animal Care Core on projects evaluating the metabolic effects of bariatric
surgery, and with the Microbiome Core to coordinate microbiome and metabolomic
analyses and interpretation. Continuous glucose monitoring (CGM) in conscious
unrestrained mice is in development and expected to be offered in the near

The Core is led by Dr. Peter Havel, DVM, PhD and Co-led by Dr.’s Fawaz Haj, PhD
and Oliver Fiehn, PhD. Other Core members include Dr. Mark Huising and Staff
Research Associate, James Graham.
Center Core RRID SCR_015359 (Link)

Peter HavelUniversity of California - Davispjhavel@ucdavis.eduDirector
Fawaz HajUniversity of California - Davisfghaj@ucdavis.eduCo-Director
James GrahamUniversity of California - Davisjlgraham@ucdavis.eduCoordinator


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