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Experiment

Changes in the gut microbiota with different variations of biliary diversion
surgery
Summary Data Summary
Investigator Yin, Dengping
Description To determine the effects of bile diversion on weight loss and reversal of
metabolic dysregulation, 3 mouse models were developed in which the gall bladder
was anastomosed to the duodenum (CD), jejunum (CJ), or ileum (CI). The gall
bladder-duodenum anastomosis served as the surgical control since the bile flow
was unaltered. Control mice were fed either chow or 60% high fat diet. High fat
diet animals were assigned to surgical group or left unoperated as diet control.
The effect of the bile acid diversion site on the cecal microbiota profile was
examined.
Status Completed
Public Release 2/28/2018
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame StrainExperiment Description
Data Analysis
TypeCount
Animals25
Experimental Conditions3
Catalog Items1
Curation Info (# flags)2
Phenotype Assays1
Phenotype Measurements25
Histology Images0
Publications1
External References2
Documents2


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
0
25
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment
This animal belongs to experimental group that is homozygous for gene manipulations.

Experimental Factor: Mouse Diet

 BioServ F3282
Rodent Hig Fat Diet. Protein 20.%, Fat 35.5%, Fiber 0.0%, Ash 3.2%, Moisture <5.0%, Carbohydrate 36.3%. Ingredients: Lard, Casein, Dextrose, Sucrose, DL-Methionine, Choline Chloride, Vitamin Mix and Mineral Mix
 Teklad - 2018
2018 Teklad Global 18% Protein Rodent Diet is a fixed formula, non-autoclavable diet manufactured with high quality ingredients and designed to support gestation, lactation, and growth of rodents. 2018 does not contain alfalfa, thus lowering the...

Experimental Factor: Surgical Procedure

 BD-D-Sham
Sham experiment for the Bile diversion procedures (Bile diversion to the duodenum)
 BD-IL
Bile diversion to the ileum. In this procedure the common bile duct is ligated proximal to the confluence of the common bile and the pancreatic ducts. An anastomosis is created at the ileum to re-establish drainage of the biliary tree.
 BD-J
Bile diversion to the jejunum. In this procedure the common bile duct is ligated proximal to the confluence of the common bile and the pancreatic ducts. An anastomosis is created at the jejunum to re-establish drainage of the biliary tree.
 Unmanipulated
Control for surgical procedure where animal has not been manipulated
Experimental Factor (Units)
Experimental Group
Mouse Diet
Surgical Procedure


Phenotype Assays Add / Edit



No documents found.

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