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Experiment

Effect of altered light cycle (5 day darkness) on energy expenditure and meal
patterns in mouse model of Prader-Willi syndrome
Summary Data Summary
Investigator LaSalle, Janine
Description Effect of altered light cycle (5 day darkness) on energy expenditure and meal
patterns in female mice in a mouse model of Prader-Willi syndrome

3 full days (3 subjective light/dark cycles) used in the analysis

Snord116 deletion mice provide a mouse model of Prader-willi syndrome when the
deletion is carried on the paternally inherited allele.

Applicable research area(s): Obesity, Metabolism, Neurobiology
Status Completed
Public Release 6/14/2018
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagSame Strain
Data Analysis
TypeCount
Animals16
Experimental Conditions2
Catalog Items1
Curation Info (# flags)1
Phenotype Assays49
Phenotype Measurements784
Histology Images0
Publications0
Phenotypes14


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
8
0
0
Snord116 -/+
8
0
0


Experimental Conditions
NameUnits
Experimental Groupone of [Control, Control-Het, ...]
Mouse Dietone of [3mAIN76(HF0.18), 3mAIN76(HF0.18)early, ...]


Phenotype Assays Add / Edit

NameAbbreviation
body mass
W rodent
oxygen consumption (Light Period)
VO2-L
fat body mass
fat body mass
lean body mass
lean body mass
respiratory exchange ratio (Light Period)
RER-L
bone mineral density
BMD
bone mineral content
BMC
bone area
bone area
fat tissue, %
% body fat
heat (Light Period)
HEAT-Light
oxygen consumption (Dark Period)
VO2-D
carbon dioxide production Light Period
VCO2-L
carbon dioxide production Dark Period
VCO2-D
respiratory exchange ratio (Dark Period)
RER-D
heat (Dark Period)
HEAT-Dark
carbon dioxide production
VCO2
heat
HEAT
oxygen consumption
VO2
respiratory exchange ratio
RQ
energy intake (Light Period)
food intake - light
food intake (Dark Period)
food intake - dark
energy intake (avg 24 hr)
energy intake avg 24
energy intake (Ligth Period)
energy intake -light
energy intake (Dark Period)
energy intake - dark
Activity 24h (total x-axis)
Activity 24h total x
Activity 24h (x-ambulatory)
Activity 24h (x-amb)
Activity 24h (total vertical z-axis)
Activity 24h total z
total tissue mass
TTM
heat (24hr)
heat - 24h
meal duration (Avg) - Active Eating Time
avg meal dur AET
meal size (Avg)
avg meal size
meals, number
num meals
inter-meal interval, average
avg IMI
meal duration (total)
total meal duration
satiety ratio
satiety ratio
eating rate, average
avg eating rate
meal duration, average light
avg light-meal dur
meal duration, average dark
avg dark-meal dur
meal size, average light
avg light-meal size
meal size, average dark
avg dark-meal size
inter-meal interval, average light
avg light-IMI
inter-meal interval, average dark
avg dark-IMI
meals, number light
light-num meals
meals, number dark
dark-num meals
satiety ratio, light
light-satiety ratio
satiety ratio, dark
dark-satiety ratio
eating rate, light
light-eating rate
eating rate, dark
dark-eating rate
food intake
food intake



No documents found.


Mammalian Phenotype (MP) Terms

MPTermIDMPTermNameDefinitionOther Results
MP:0000063decreased bone mineral density
reduction in the quatitative measurment value of mineral content of bone; BMD is used as an indicator of bone strength used as a measure of structural strength and screen for osteoporosis; bone mineral density is the ratio of bone mineral content to bone size [ISBN:0-683-40008-8| MGI:csmith]
MMPC Search Results
MP:0001262decreased body weight
lower than normal average weight [PMID:10709991]
MMPC Search Results
MP:0003961decreased lean body mass
reduced amount of the fat-free physical bulk or volume of the body including all its components except adipose (fat) tissue [MGI:csmith]
MMPC Search Results
MP:0005289increased oxygen consumption
greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body [MESH:G06.535.723]
MMPC Search Results
MP:0005459decreased percent body fat/body weight
less fat| relative to controls| expressed as a percentage of total body weight [MGI:cwg]
MMPC Search Results
MP:0008963increased carbon dioxide production
increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas [MGI:csmith]
MMPC Search Results
MP:0010025decreased total body fat amount
less than the normal total amount of connective tissue composed of fat cells within the entire body [MGI:csmith]
MMPC Search Results
MP:0010124decreased bone mineral content
reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area [MGI:csmith]
MMPC Search Results
MP:0010968decreased compact bone area
reduction in the total amount of cross-sectional area of compact bone tissue [MGI:csmith]
MMPC Search Results
MP:0013616decreased volumetric bone mineral density
reduction in the mineral mass per unit volume of bone| the hard| rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; this is expressed as the amount of mineral per cubic cm of bone (usually in mgHA/cm^3)| with results generated from Quantitative computed tomography (QCT) and other tests [PMID:12730800| PMID:17481978]
MMPC Search Results
MP:0013618decreased areal bone mineral density
reduction of the mineral mass per unit area of bone| the hard| rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; expressed as the amount of mineral per area cm^2 of bone (usually in g/cm^2)| with results generated from Dual-energy X-ray absorptiometry (DXA or DEXA) tests [PMID:12730800| PMID:17481978]
MMPC Search Results
MP:0014025decreased subchondral bone mineral content
decreased amount (usually in grams/cm) of bone mineral divided by a bone-scanned area in the bone region of the epiphysis that provides underlying mechanical and physiological support for the cartilage of joint articular surfaces [MGI:csmith| PMID:20392241]
MMPC Search Results
MP:0014143decreased body fat mass
decreased physical bulk or volume of fat in the whole body [MGI:csmith]
MMPC Search Results
MP:0020010decreased bone mineral density of femur
reduction in the quatitative measurment value of mineral content of bone in the long bone of the thigh [http://orcid.org/0000-0001-5208-3432]
MMPC Search Results

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