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Analysis of energy expenditure and core temperature during temperature challenge
in a model of malignant hyperthermia
Mutations in either type 1 ryanodine receptor (RyR1) cause malignant
hyperthermia susceptibility (MHS) in humans and animals. It is necessary to
understand how altered RyR1 channel regulation influences basal changes in
mitochondrial bioenergetics, produces oxidative stress, and promotes progressive
muscle damage. This study evaluates the thermal neutral zone in control and Ryr1
heterozygote mutant mice (Males and females). This high resolution testing
includes core temperature readings allowing us to better characterize how
ambient temperature influences heat stress in MHS mice. Animals were implanted
with DST nano-T temperature recorders and allowed to recover for at least 10
days. Animals were subjected to indirect calorimetry to assess heat at
environmental temperatures 15-37C.
week(s) post-natal (w)
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Curation Info (# flags)
Name / Abbreviation
Experimental Factor: Environmental Temperature (°C)
The temperature of the environment when the measurement was taken.
Experimental Factor: Experimental Group
This animal belongs to the control group for the experiment.
This animal belongs to the experimental group and is heterozygous wild type/mutation for the affected locus.
Experimental Factor (Units)
Environmental Temperature (°C) (°C)
Add / Edit
energy expenditure, basal
energy expenditure, basal
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Mammalian Phenotype (MP) Terms
increased body temperature
greater than the level of heat natural to a living being [ISBN:0-683-40008-8| MGI:cwg| RGD:cur]
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Financial support for this work was provided by the NIDDK Mouse Metabolic Phenotyping Centers (National MMPC, RRID:SCR_008997,
) under the MICROMouse Program, grants DK076169.
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