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Experiment

Analysis of energy expenditure and core temperature during temperature challenge
in a model of malignant hyperthermia
Summary Data Summary
Investigator Pessah, Isaac
Description Mutations in either type 1 ryanodine receptor (RyR1) cause malignant
hyperthermia susceptibility (MHS) in humans and animals. It is necessary to
understand how altered RyR1 channel regulation influences basal changes in
mitochondrial bioenergetics, produces oxidative stress, and promotes progressive
muscle damage. This study evaluates the thermal neutral zone in control and Ryr1
heterozygote mutant mice (Males and females). This high resolution testing
includes core temperature readings allowing us to better characterize how
ambient temperature influences heat stress in MHS mice. Animals were implanted
with DST nano-T temperature recorders and allowed to recover for at least 10
days. Animals were subjected to indirect calorimetry to assess heat at
environmental temperatures 15-37C.
Status Completed
Public Release 6/14/2018
Animal Age Measured In: week(s) post-natal (w)
Flags has-data-flagAnimal Count
Data Analysis
TypeCount
Animals14
Experimental Conditions2
Catalog Items2
Curation Info (# flags)1
Phenotype Assays2
Phenotype Measurements6160
Histology Images0
Publications0
Phenotypes1


Animals

Strain NameCommon NameFemalesMalesUnknown
C57BL/6
0
7
0
RyR1-R163C
0
7
0

Experimental Factors
 Categorical Values
Name / AbbreviationDescription

Experimental Factor: Environmental Temperature (°C)

 env temp
The temperature of the environment when the measurement was taken.

Experimental Factor: Experimental Group

 Control
This animal belongs to the control group for the experiment.
 Experiment-Het
This animal belongs to the experimental group and is heterozygous wild type/mutation for the affected locus.


Phenotype Assays Add / Edit



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